Save Big on Muscle-Building Supplements like Protein Powder and Creatine During Prime Day

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PRIME DAY IS a great time to save on supplements. As someone who regularly takes protein powder, creatine, magnesium, and vitamin D, I can confirm that your supply of these products runs out quicker than you can ever imagine. So stocking up on a discount is never a bad idea.

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Sure, other purchases like high-def TVs and smart tech may seem more exciting, but I personally use Prime Day as an opportunity to try new everyday products I’ve been curious about or loading up on brands I already enjoy. If you’re preparing to try a new supplement, keep in mind that they are meant to support a well-balanced diet, not replace it. And it’s always a good idea to check with your doctor if you have any questions.

Rest assured, our standards are pretty high, and I’ve made sure to include products that are third-party tested. This means they have been analyzed by an outside entity to ensure that what’s in the bottle matches what they have put on the ingredient list. We’ll be sure to continue to update this list as we spot new great deals.

Prime Day Supplements 2026 Deals

Optimum Nutrition Gold Standard 100% Whey Protein Powder

Orgain Vegan Protein Powder (Vanilla Bean)

Transparent Labs Creatine HMB

Thorne Creatine + Alpha GPC

Ascent Creatine Monohydrate Powder

Nuun Sport Hydration

Vital Proteins Collagen Peptides

Thorne Magnesium Glycinate

Ritual for Men 18+

Nature Made Magnesium (200 mg)

Garden of Life Once Daily Men’s Probiotic

Nature Made Vitamin B12 (1000 mcg)

Transparent Labs Bulk Pre Workout Powder

Why These Are Our Picks

My two go-to items to pick up during Prime Day events are protein powder and creatine, both of which have plenty of deals to get excited about. Optimum Nutrition Gold Standard 100% Whey is one of our favorite whey protein powders, thanks to its high-quality ingredients, great taste, and availability on distributors like Amazon. For this reason, it is featured as our best value protein powder in our best protein powders guide. Same goes for our Transparent Labs Whey Protein, which can be seen in the guide as the best high-quality whey protein. Our guide also spotlights Orgain Vegan Protein Powder, which is perfect for anyone who is on the look out for a plant-based or vegan protein powder option.

As I mentioned, along with protein powder, creatine is one of the best products to pick up during these sales. Especially if it is third-party tested and unflavored, like Thorne’s Creatine + Alpha GPC, if you’re looking for a flavored powder to put in your water, or Ascent’s Clean Creatine, if you’re looking for a smaller container. But our favorite pick is Transparent Labs’ Creatine HMB, which is featured in our best creatines guide.

If you don’t already take a magnesium supplement, you’ve probably heard quite a bit about the benefits. If you’re looking for non-OTC ways to improve your sleep quality, this might be your key, and our favorite magnesium supplement, Thorne’s Magnesium Glycinate, is on sale.

Ritual’s Multivitamin has spent a lot of time at the top of our favorite multivitamins, and is featured in our best multivitamin guide. The company does a subscription service, that allows you to save when you sign up, but nobody wants to sign up for a membership without knowing they like the product. That’s why we like this Prime Day deal, because it allows you to pick up a bottle or two at a discount.

If you’re in the market for a pre-workout, Transparent Labs’ Bulk Pre-Workout was our pick for best overall option in our guide. There are also a few USP-certified options from Nature Made for those individuals who have started to incorporate, or are looking to incorporate, supplements like magnesium and B12 into their routine. For even more options, be sure to check out our best magnesium guide and our best B12 supplement guide.

This summer has been especially hot, which probably has quite a few people looking for hydration options. We spotted some great deals happening on electrolytes from Nuun, but be sure that you are snagging the sugar-free version, as it cuts down on the additives. My personal preference is the lemon-lime flavor, but other options are also on sale. For more options, be sure to check out our best electrolytes guide, which we will continue to update.

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